Recent advances on the neuroprotective role of the novel TLDC proteins against oxidative stress

Mattea-Finelli-Paris-redox-2019Dr. Mattéa Finelli from the University of Oxford, United Kingdom will join us again at the Paris Redox 2019 congress and will share the results and discovery on the research "Recent advances on the neuroprotective role of the novel TLDC proteins against oxidative stress".

Dr. Finelli’s research focuses on the role played by oxidative stress (OS) in the process of neuronal cell death, which is a key feature observed in many neurodegenerative conditions. Dr Finelli investigates the role of a family of proteins - the TLDc proteins - that are neuroprotective against OS. Dr Finelli described her novel findings on the mechanisms of action of one of the TLDc proteins: oxidation resistance 1 (Oxr1). She showed how Oxr1 interacts with the essential multifunctional enzyme, glucose-6-phosphate isomerase (Gpi1), and how it controls Gpi1 activity and functions through regulation of its oligomerization. This leads in turn to modulation of OS levels and neuronal cell survival.

 

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