Oxidative stress (OS) had been evaluated in NSCLC using photoproduced singlet oxygen (1O2) deactivating by oxydizing its targets directly or through secondary reactive oxygen species (SOS) production. Either experimentally (orthotopic grafts in mice) or clinically OS changed non linearly with progression. At time of cachexia OS dramatically increased when at a resectable stage in was lower than in controls. According Pr Patrice Thierry from CHU de Nantes, there was a trend to an inverse relationship OS/Vit D. An eventual adjuvant supplementation during cancers should by controlled on a per-patient basis.
To know more about Paris Redox World Congress 2016, please click here.