Role of oxidative stress in Pathogenesis of Parkinson's disease (PD)

The Scientific Committee of Paris Redox 2019 is honoured to be welcoming Dr. Om P. Gulati, Director of Research and Development, Horphag Research in Switzerland, for the 21st International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants.

For this new congress, Dr. Gulati will discuss about " Role of oxidative stress in Pathogenesis of Parkinson's disease (PD)".

Summary of presentation: "Oxidative stress represents an imbalance, between high production of free radicals, reactive oxygen species (ROS) and cellular antioxidant activity. The presence of ROS-generating enzymes such as tyrosine hydroxylase (TH) and monoamine oxidase (MAO), the DAergic neurons are particularly prone to oxidative stress.

Diabetes-2 is characterized by selective damage or loss of beta cells of pancreas caused by free radicals, resulting in decreased secretion or absence of insulin.

Parkinson's disease (PD) is associated with a selective loss of the neurons in the midbrain area called the substantia nigra, pars compacta. As these neurons control voluntary movements, their degeneration leads to four cardinal signs and debilitating symptoms: resting tremor, muscular rigidity, bradykinesia, and postural imbalance.

Diabetes-2 predisposes to PD and makes the neurons of substantia nigra more prone to their further damage and/or their loss caused by free radicals resulting in advancement of PD".

For more information about this presentation and Paris Redox Congress: www.isanh.net