Interplay between reactive oxygen and nitrogen species in cancer cell fate determination

Shazib Paris Redox 2018

Dr. Shazib Pervaizfrom the National University of Singapore, Singapore will give a strategic presentation on the Interplay between reactive oxygen and nitrogen species in cancer cell fate determination during Paris Redox 2018 congress.

Dr. Pervaiz is currently spearheading a research group investigating cellular redox status and its impact on cancer cell fate decisions. Using a variety of model systems, his group has been investigating the molecular mechanisms of drug resistance in human cancers with an overall objective of identifying novel pathways and targets for therapeutic intervention.

According to Dr Pervaiz: "Superoxide mediated signalling promotes oncogenesis by creating an intracellular milieu permissive for cell survival and proliferation.  Our recent work provides evidence that this oncogenic activity of superoxide is a function of an environment that facilitates its reaction with nitric oxide rather than its dismutation to hydrogen peroxide.  As such, the intracellular ratio of iNOS to SOD might be a critical determinant in the process of carcinogenesis and its progression."

For more information: www.isanh.net