Oxidative stress, antioxidant genes and satellite cells in muscle regeneration: cross-talks with microRNAs

josef dulakProf. Józef Dulak from the Department of Medical Biotechnology at Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University (Krakow, Poland) will present the role of oxidative stress, antioxidant genes and satellite cells in muscle regeneration, and the impact of the cross-talks with microRNAs.

Regeneration of skeletal muscles is dependent on satellite cells, the bona fide stem cells, able to differentiate to myoblasts forming muscle fibres. Recently Prof. Dulak's team showed that heme oxygenase-1 (HO-1, Hmox1), a major anti-oxidant and cytoprotective gene is also involved in satellite cells differentiation and muscle regeneration, revealing also the potent effect of HO-1 on microRNAs. Disturbance in these interactions may lead to development of rhabdomyosarcoma, a major soft tissue tumor in children, while insufficient expression of HO-1 may aggravate the muscle damage and Duchenne muscular dystrophy progression. In this talk the role of HO-1 and its upstream Nrf2 will be discussed.

The results of this study will be presented during Paris Redox 2018 International Conference, which will be held in Paris on June 25-26, 2018.

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