Redox Metabolism of Hydrogen Sulfide (H2S) and Reactive Sulfide Species (RSS): Emerging concepts in cell signaling and therapeutic applications

kenneth olson-paris redox 2017

The scientific committee of Paris Redox 2018 is honoured to welcoming Pr Kenneth R. Olson, Emeritus Professor of Physiology at Indiana University School of Medicine - South Bend, USA for the 20th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants.

Prof. Olson will chair the strategic session dedicated to Reactive Sulfide Species, Oxidative Stress and Redox Regulation-Modulation. 

According to Pr Olson: "There is increasing evidence that reactive sulfide species (RSS) are endogenous signaling molecules that are chemically similar to reactive oxygen species (ROS) and target common physiological effectors.  Because RSS were far more prevalent than ROS throughout most of evolution, I have proposed that much of this primordial metabolic “machinery” persists in modern animals but has been largely overlooked due to various factors including, research “oxycentrism”, difficulties in distinguishing RSS from ROS, and uncertainties about metabolic pathways regulating RSS metabolism.  In this talk I will discuss these factors and describe recent work from my laboratory on RSS metabolism by classical antioxidant systems that points to a long-standing yet overlooked redox regulatory system. These findings further question the paradigm that the most biologically relevant oxidants are ROS and they suggest that further research into RSS is imperative."

For more information about this session and Paris Redox Congress: