Dr Hongli Wu from the University of North Texas Health & Science Center will give a short presentation about the protein glutathionylation and age-related macular degeneration during the special session on oxidative stress and ocular diseases of Paris Redox Congress.
Accumulating evidence suggests that oxidative stress plays a central role in the pathogenesis of age-related macular degeneration (AMD). In this presentation we will talk about the essential roles of glutaredoxin 2 (Grx2), a newly identified mitochondrial antioxidant enzyme, in protecting the retina against oxidative stress induced tissue damage. More importantly, we found that Grx2 gene knockout mice show age-dependent deceleration of visual function accompanied by an AMD-like phenotype, including the presence of sub-RPE deposits, RPE pigmentary changes, RPE atrophy, and increased autofluoresence. These results not only can expand our knowledge on the mechanism of AMD but also can expose Grx2 as a novel pharmaceutical target for AMD treatment.
To access to the different presentations of this session, please follow this link.