Role of the peroxiredoxin 1 in the protection of the telomeres from oxidative stress damage

joachim lingner paris redox 2017Dr Joachim Lingner from the Ecole Polytechnique Fédérale de Lausanne in Switzerland is one one the invited speaker of Paris Redox World Congress 2017.

Dr Lingner is one of the international expert in the telomeres and he will give a presentation about the role of the peroxiredoxin 1 to protect telomeres from the oxidative damage.

According to Dr Lingner: Telomere damage and shortening has been implicated in aging, cancer development and in telomeropathies in which patients suffer from bone marrow, lung or liver abnormalities. Telomeric DNA appears particularly sensitive to chemical damage possibly due to the G-tracts in telomeric repeats or because telomeres suppress certain DNA repair pathways. I will report on how telomeres may compensate for their enhanced vulnerability to oxidative stress by recruiting the oxygen radical scavenger peroxiredoxin 1 (PRDX1) to telomeric chromatin. We find that PRDX1 depletion leads to oxidative damage of telomeric DNA. Furthermore, we identify specific defects of telomerase when attempting to elongate oxidized DNA substrates.   

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