News
Mitochondrial Involvement in Different Model Systems of Ferroptosis
Ms. Melanie Merkel, Philipps-Universität Marburg, Germany, will join the Redox Medicine 2023 congress and present her research on "Mitochondrial Involvement in Different Model Systems of Ferroptosis".
Ferroptosis is a form of caspase-independent cell death mediated by iron-dependent accumulation of reactive oxygen species (ROS), predominantly through lipid peroxidation, mitochondrial impairments and pronounced mitochondrial ROS formation. Oxidative cell death through ferroptosis can be triggered by different agents, like erastin, RSL-3 or hemin, and each of these model compounds may initiate slightly different cascades of ferroptosis with varying mitochondrial involvement.
Ms. Merkel and her team investigated various intervention strategies for mitochondrial protection and according effects in the respective model systems of ferroptosis to identify differences in mitochondrial involvement and potential therapeutic approaches.
Join Redox Medicine 2023 to learn more about Ms. Merkel's interesting talk.
You can submit a related abstract here.
Redox Medicine 2023 Congress
June 21-23, 2023 - Paris, France
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Chronobiology : The Reactive Species Interactome-Mitochondria axis, the hands of the circadian clock ?
Dr. Laurent Chatre, Normandie University, UNICAEN Cyceron, Centre national de la recherche scientifique (CNRS), and an active Member of the Redox Medicine Society scientific committee will join Redox Medicine 2023 on June 21-23 to present a talk entitled "Chronobiology : The Reactive Species Interactome-Mitochondria axis, the hands of the circadian clock ?".
First, Dr. Chatre will introduce the field of chronobiology – how mammalian circadian clocks operate from the perspectives of both redox pathways, and mitochondrial homeostasis. He will then present results from global proteomic, metabolic and redox analysis on wildtype and restricted-fed animals over circadian time. This comprehensive analysis indicates, for the first time, that the reactive species interactome (RSI) is under tight circadian control and the RSI, in turn, can tune oscillator properties such as the 24hr circadian period. Finally, consequences of circadian disruption and perspectives will be discussed. More about Dr. Chatre's research.
Check the comments of the scientific committee on this topic.
Join Redox Medicine 2023 to learn more about Dr. Chatre's interesting talk. You can submit a related abstract here.
Redox Medicine 2023 Congress
June 21-23, 2023 - Paris, France
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Effects of reactive sulfur species in macrophage activation and regulation of apoptosis/necrosis pathways in cancer cells
Dr. Moran Benhar from Technion university, Israel will join Redox Medicine 2023 on June 21-23 to present a talk entitled "Effects of reactive sulfur species in macrophage activation and regulation of apoptosis/necrosis pathways in cancer cells".
Hydrogen sulfide (H2S) and related reactive sulfur species (RSS) are widely implicated in inflammatory and cell death responses. Dr. Moran Benhar will present his recent work on the mechanisms by which H2S/RSS regulate cell death and inflammatory signaling.
He will summarize recent progress on the role of RSS in the control of apoptosis and necroptosis in tumor cells. He will also present new findings on the regulation of protein persulfidation in macrophages, and the role of persulfidation in the macrophage cell response to oxidative and inflammatory stress.
Join Redox Medicine 2023 to learn more about Dr. Benhar's interesting talk. You can submit a related abstract here.
Redox Medicine 2023 Congress
June 21-23, 2023 - Paris, France
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Awakening Adult Retinal Stem Cells: A New Function of NOX Signaling in the Xenopus Retina
Dr. Morgane Locker from Université Paris-Saclay, France will join the Redox Medicine 2023 on June 21-23 to present a talk entitled "Awakening Adult Retinal Stem Cells: A New Function of NOX Signaling in the Xenopus Retina".
Using the amphibian retina as a model system, Dr. Locker's team aimed at deciphering how the redox state might impact neural stem cell activity. Their functional in vivo investigations show that NADPH oxidase (NOX)-dependent ROS production controls retinal stem cell transition from quiescence to proliferation. Dr. Locker's team further reveal that such effect is mediated through regulation of the Wnt/Hedgehog signalling balance. Altogether, Dr. Locker's team's study highlights NOX as a novel player of the regulatory network that fine-tunes neural stem cell proliferation within the post-embryonic neurogenic niche of the retina.
Join Redox Medicine 2023 to learn more about Dr. Locker's interesting talk. You can submit a related abstract here.
Redox Medicine 2023 Congress
June 21-23, 2023 - Paris, France
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Redox Homeostasis and Sarcopenia: Targeting Mitochondria
Prof. Francesco Bellanti, University of Foggia, Italy will present a talk entitled "Redox Homeostasis and Sarcopenia: Targeting Mitochondria" during Redox Medicine 2023 this June.
Defined by the age-related loss of skeletal muscle quality, sarcopenia is dependent on mitochondrial homeostasis and redox balance. Redox impairment occurs during aging, and altered oxidative reactions are mostly caused by injury of several mitochondrial features such as bioenergetics, biogenesis, dynamics, and selective autophagy (mitophagy).
Redox imbalance and mitochondrial dysfunction affect protein homeostasis, resulting in deficient muscle mass and function. Thus, mitochondria are indicated as potential targets to prevent and treat this age-related condition. Promising mitochondria-targeted drug delivery systems, including compounds that enhance bioenergetics, scavenge reactive species, prevent apoptosis, and target mitophagy are promising in preclinical investigations, but their use needs to be tested in clinical trials.
There is a fascinating need to better understand the redox pathways modulating mitochondrial homeostasis and to characterize molecules that target skeletal muscle mitochondria to counteract sarcopenia in aging.
Join Redox Medicine 2023 to learn more about Prof. Bellanti's interesting talk. You can submit a related abstract here.
Redox Medicine 2023 Congress
June 21-23, 2023 - Paris, France
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