Gestational Diabetes Mellitus and Fetal Endothelial Dysfunction
Dr. Luis Sobrevia from Pontifician Universidad Católica de Chile, Chile, will present his most recent findings on the "'Gestational Diabetes Mellitus and Fetal Endothelial Dysfunction".
Gestational diabetes mellitus (GDM) is a disease of pregnancy that associates with fetoplacental endothelial dysfunction. GDM associates with increased generation of the free radicals scavenging the nitric oxide reducing its availability for umbilical vein dilation. Women with prepregnancy obesity that develop GDM (i.e. gestational diabesity) show endoplasmic reticulum stress including increased hCHOP/C-EBP complex activation and reduced expression of SLC29A1 and SLC29A2 genes (for human equilibrate nucleoside transporters 1 and 2, respectively) in a NO dependent manner. A role for the synthesis of mitochondrial-derived superoxide anion is likely in GDM and gestational diabesity in human fetal endothelium.
Join us in Paris Redox 2022 Congress to benefit from the experience of professional speakers like Dr. Sobrevia.
24th Annual ISANH Meeting
Paris Redox 2022 Congress
June 22-24, 2022 - Paris, France
www.isanh.net
