N-Acetylcysteine (NAC) and Hydrogen Sulfide (H2S): A Convenient Rationale for Coronavirus Disease 2019 (COVID-19)?

Dr. Arno Bourgonje from University Medical Center Groningen, The Netherlands, will present a talk entitled "N-acetylcysteine (NAC) and Hydrogen Sulfide (H2S): A Convenient Rationale for Coronavirus Disease 2019 (COVID-19)?".

Accumulating evidence provided by Dr. Bourgonje suggests that hydrogen sulfide (H₂S) may have a modulatory role in the pathophysiology of coronavirus disease 2019 (COVID-19). Dissecting the relevant molecular pathways reveals the existence of both antiviral and antioxidant effects of H₂S, which may therefore constitute a versatile and modifiable host factor in patients with COVID-19. N-acetylcysteine (NAC) is a renowned pharmacological antioxidant substance acting as a source of cysteine, thereby promoting endogenous glutathione (GSH) biosynthesis as well as the generation of sulfane sulfur species when desulfurated to H₂S. Clinical trials are currently on their way to demonstrate the potential effectiveness and applicability of NAC supplementation to promote endogenous H₂S production in patients with COVID-19. Should we aim for the application of H₂S-targeted therapeutics in COVID-19?

Paris Redox 2021 Congress
October 13-15, 2021 - Paris, France & Online
www.isanh.net