Safe utilisation of dietary sugars requires dynamic control of redox balance - Paris Redox World Congress 2020 - October 8 - 9, 2020 - Paris, France

Safe utilisation of dietary sugars requires dynamic control of redox balance

Dietary sugars, such as glucose, are sensed intracellularly by a regulatory system, which includes transcription factor Mondo-Mlx and protein kinase SIK3. Together they control the expression and activity of Glucose-6-phosphate dehydrogenase, which maintains cellular redox balance. Credit: Mari Teesalu

The regulatory system to control redox balance involves sugar-dependent gene regulation and protein phosphorylation. Without dynamic control of redox balance animals lose their ability to survive on sugar-rich food.

 

Animal diet has a tremendous natural variation, ranging from meat-eating carnivores to sugar-loving nectarivores. Omnivores, like humans, can adopt different types of diets and still remain healthy. However, if the diet is highly unbalanced and calorie rich, it will eventually lead to metabolic problems and disease. The genetic factors of the individual define how easily and quickly such problems develop.

"A key to the nutritional flexibility of the animals is the ability of the body to monitor its nutrient status and regulate metabolism accordingly. Many metabolic pathways depend on reduction and oxidation (redox) reactions. That is why coordinating the redox balance with cellular metabolism is critical", describes Associate Professor Ville Hietakangas from the University of Helsinki.

The system how the redox balance is controlled in response to changes of sugar feeding has so far been insufficiently understood. Now the study by Mari Teesalu, Bohdana Rovenko and Ville Hietakangas reveals a new mechanism that allows animals to increase their reductive power during conditions of high sugar intake.

"This reductive power is necessary to allow conversion of excess sugar into fat and provide protection against oxidative stress that can occur during . Without the mechanism to increase the reductive power after sugar feeding larvae of fruit fly Drosophila melanogaster lose their sugar tolerance, and they are not able to grow and survive on high sugar diet", says Hietakangas.

The new regulatory mechanism involves protein kinase SIK3, which controls the activity of other proteins by phosphorylating them. SIK3 phosphorylates and activates a key enzyme of glucose metabolism called Glucose-6-phosphate dehydrogenase G6PD, which is an important regulator of cellular redox .

SIK3 controls G6PD in synergy with another important regulator of sugar tolerance, the sugar-sensing transcription factor complex Mondo-Mlx. Simultaneous inhibition of SIK3 and Mondo-Mlx leads to devastating consequences, causing lethality even on moderate levels of dietary .

 

News source: www.medicalxpress.com

Redox in the Press & Media

A New Blood Component Revealed

A New Blood Component Revealed

03-02-2020 Hits:138

Functional extracellular mitochondria revealed in the blood circulation. ©Alain R. Thierry/Inserm   Does the blood we thought to know so well contain elements that had been undetectable...

Read more
Hydrogen sulfide: a target to modulate oxidative stress and neuroplasticity for the treatment of pathological anxiety

Hydrogen sulfide: a target to modulate oxidative stress and neuroplasticity for the treatment of pathological anxiety

09-12-2019 Hits:335

We remind you that during Paris Redox 2020, a specific session will be dedicated to Redox, H2S and Microbiota. We selected for you paper published by...

Read more
SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice

SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice

06-12-2019 Hits:322

Redox imbalance induces oxidative damage and causes age-related pathologies. Mice lacking the antioxidant enzyme SOD1 (Sod1-/-) exhibit various aging-like phenotypes throughout the body and are...

Read more
Hydrogen Sulfide: Recent Progressxion and Perspectives for the Treatment of Diabetic Nephropathy

Hydrogen Sulfide: Recent Progressxion and Perspectives for the Treatment of Diabetic Nephropathy

05-12-2019 Hits:215

Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major cause of chronic kidney diseases (CKD) and end stage kidney disease...

Read more
New cause of cell aging discovered

New cause of cell aging discovered

26-07-2019 Hits:619

    Cells illustration (stock image). Credit: © Anusorn / Adobe Stock   New research from the USC Viterbi School of Engineering could be key to our understanding of how...

Read more

Paris Redox 2019: A round table discussion dedicated to Reactive Species Interactome by Prof Marvin Edeas

01-03-2019 Hits:4058

Marvin Edeas, chairman of the Scientific Committee of Paris Redox 2019, Institut Cochin, Inserm U1016, University Paris Descartes, France will moderate a round table discussion...

Read more
Study Provides New Insights For Ways to Use Cell Metabolism to Treat Cancer

Study Provides New Insights For Ways to Use Cell Metabolism to Treat Cancer

31-08-2018 Hits:1198

Researchers at the University of Cincinnati (UC) College of Medicine have discovered that cell metabolism plays an important role in the ability of cells to...

Read more
Scientists reverse Aging-associated skin wrinkles and hair loss in a mouse model

Scientists reverse Aging-associated skin wrinkles and hair loss in a mouse model

23-07-2018 Hits:1753

Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed? Keshav Singh, Ph.D., and colleagues have done just that, in a...

Read more

Beef jerky and other processed meats associated with manic episodes

19-07-2018 Hits:1176

An analysis of more than 1,000 people with and without psychiatric disorders has shown that nitrates—chemicals used to cure meats such as beef jerky, salami...

Read more

Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation

29-06-2018 Hits:1309

Mutations led to resistance by up-regulating beta-lactamase and multi-drug efflux pump. Antibiotic resistance poses a major threat to public health. Overuse and misuse of antibiotics are...

Read more

Is There a Link Between Diabetes and Parkinson's Disease?

20-06-2018 Hits:1294

People with type 2 diabetes may have an increased risk of having a diagnosis of Parkinson's disease later in life, according to a large study...

Read more
Imaging Method Evaluates Cell Functional Changes and Wound Healing

Imaging Method Evaluates Cell Functional Changes and Wound Healing

16-04-2018 Hits:1342

Optical redox ratio maps of fibroblasts isolated from young and aged rats. Red regions correspond to high redox ratios, while blue regions correspond to low...

Read more

Can Vitamins and Supplements Help Patients with Mitochondrial Disease?

05-04-2018 Hits:1309

Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can...

Read more
'Natural insecticide' kills advanced prostate cancer cells: A Mitochondria issue

'Natural insecticide' kills advanced prostate cancer cells: A Mitochondria issue

05-04-2018 Hits:1280

  Researchers reveal how a 'natural insecticide' can destroy advanced prostate cancer cells.   One of the hallmarks of advanced prostate cancer is a faulty PTEN tumor suppressor...

Read more

Cells stressed out? Make mitochondria longer

05-04-2018 Hits:1175

Scientists at The Scripps Research Institute (TSRI) have discovered a new pathway in cells that promotes mitochondrial function during times of stress, a response that...

Read more

Microcapsules Gain a New Power - Scavenging Reactive Oxygen Species

31-01-2018 Hits:1522

Stable, biocompatible microcapsules from the lab of Eugenia Kharlampieva have gained a new power — the ability to scavenge reactive oxygen species. This may aid microcapsule...

Read more

Non-invasive detection of oxidative-stress biomarkers in exhaled air – an overview

20-12-2017 Hits:1150

During Paris Redox Congress 2018, Dr Guillaume Suarez, Head of Environmental Engineering group at Institut universitaire romand de Santé au Travail in Lausanne, Switzerland will...

Read more

Lifespan and oxidative stress in Amish: What is the role of antioxidants?

24-11-2017 Hits:1096

In a study published in November 2017 by Prof. Douglas Vaughan, University of Chicago, it was shown that a rare genetic mutation that has boosted...

Read more

Redox biomarker could predict progression of epilepsy

08-11-2017 Hits:1664

Approximately 2.9 million people in the United States suffer from epilepsy, according to the CDC. For patients living with this diagnosis and their doctors it...

Read more
Safe utilisation of dietary sugars requires dynamic control of redox balance

Safe utilisation of dietary sugars requires dynamic control of redox balance

08-11-2017 Hits:1324

Dietary sugars, such as glucose, are sensed intracellularly by a regulatory system, which includes transcription factor Mondo-Mlx and protein kinase SIK3. Together they...

Read more
The 19th edition of Paris Redox Congress was a successful event

The 19th edition of Paris Redox Congress was a successful event

09-07-2017 Hits:914

The 19th International conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants " Paris Redox 2017" took place at Université Pierre et Marie Curie (UPMC)...

Read more
Regional fat distribution in women: The relation to metabolic hormones, risk markers and total anti-oxidant status

Regional fat distribution in women: The relation to metabolic hormones, risk markers and total anti-oxidant status

17-05-2017 Hits:1992

Cardiovascular risk in postmenopausal women has been partly attributed to increased visceral fat accumulation. The team of Dr Saleh conducted a controlled study on healthy...

Read more
  • 1
  • 2
  • 3
Prev Next